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Observe Carefully (1)crofelemer improves amounts of diazepam by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of. Crofelemer has the probable to inhibit CYP3A4 at concentrations envisioned while in the intestine; unlikely to inhibit systemically mainly because minimally absorbed.Hyponatremia: Clinically major hyponat